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Prognostic and therapeutic implications of mTORC1 and Rictor expression in human breast cancer

13 Mar 2013

Abstract excerpt

The mammalian target of rapamycin (mTOR) plays a key role in the regulation of cellular metabolism, growth and proliferation. It forms two multi-protein complexes known as complex 1 (mTORC1) and 2 (mTORC2). Raptor and Rictor are the core proteins for mTORC1 and mTORC2, respectively. This study examines the relationship between mTORC1, Rictor and Raptor mRNA expression and human breast cancer. Furthermore, the...

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PMID: 23503572
DOI: 10.3892/or.2013.2346

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