Article

Multivariable Mendelian Randomization adjusting for heritable confounding analyzes the causal effects of C-reactive protein on multiple diseases

2025-01-12

Abstract excerpt

<h4>Background</h4> C-reactive protein (CRP) is a marker of inflammation associated with autoimmune, cardiovascular, and neuropsychiatric disorders. However, it remains unclear whether CRP causally affects these traits or if observed associations result from reverse causation or confounding. Mendelian randomization (MR) uses genetic variants as instrumental variables to estimate causal effects and avoid the biase...

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Literature Corpus work: 4780a175-eade-5edb-8bf1-929538e72070
DOI: 10.1101/2025.01.08.631816

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