Article

Epigenetic Control of Hyperuricemia and Gout by Gene Writer DNMT1 and RNA Editor ADAR1: Mechanism of Gout and Amyloid Dissolution in Down Syndrome

2024-03-08

Abstract excerpt

<title>Abstract</title> <p>Although DNA methyltransferase 1 (DNMT1) and RNA editor; ADAR triplications exist in Down syndrome (DS), their specific roles remain unclear. DNMT methylates DNA, yielding S-adenosine homocysteine (SAH), subsequently converted to homocysteine (Hcy) and adenosine by S-adenosine homocysteine (Hcy) hydrolase (SAHH). ADAR converts adenosine to inosine and uric acid. We hypothesized that tar...

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Literature Corpus work: 47807311-a0fb-52b9-bb96-4f0e8dd0cd35
DOI: 10.21203/rs.3.rs-4010126/v1

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