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Article

DNMT3B rs2424913 as a Risk Factor for Congenital Heart Defects in Down Syndrome.

Genes - 24 Feb 2023

Majstorović Dijana, Barišić Anita, Božović Ivana Babić, Čače Iva Bilić, Čače Neven, Štifanić Mauro, Vraneković Jadranka

Abstract excerpt

Impairments of the genes that encode enzymes that are involved in one-carbon metabolism because of the presence of gene polymorphisms can affect the methylation pattern. The altered methylation profiles of the genes involved in cardiogenesis may result in congenital heart defects (CHDs). The aim of this study was to investigate the association between the MTHFR rs1801133, MTHFR rs1801131, MTRR rs1801394, DNMT1...

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Share to DNA (Cytosine-5-)-Methyltransferases
Share to DNA Methyltransferase 3B
Share to Down Syndrome
Share to Genotype
Share to Heart Defects, Congenital
Share to Heart Septal Defects, Atrial
Share to Polymorphism, Single Nucleotide
Share to Risk Factors

Source

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Identifiers

PMID: 36980848
DOI: 10.3390/genes14030576
PMCID: PMC10048502

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