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Article

Hyperhomocysteinemia, DNA methylation and vascular disease

1 Jan 2007

Abstract excerpt

Hyperhomocysteinemia (HHcy) has been established as a potent independent risk factor for cardiovascular disease (CVD) and the underlying mechanism is largely unknown. We were the first to propose that hypomethylation is the key biochemical mechanism by which homocysteine (Hcy) inhibits endothelial cell (EC) growth. We reported that clinically relevant concentrations of Hcy (10-50 micromol/L) exerts highly...

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Identifiers

PMID: 18067449
DOI: 10.1515/cclm.2007.350

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