Article

The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts

2023-04-14

Abstract excerpt

<title>Abstract</title> <p>Among the most common genetic alterations in the myelodysplastic syndromes (MDS) are mutations in the spliceosome gene <italic>SF3B1</italic>. Such mutations induce specific RNA missplicing events, directly promote ring sideroblast (RS) formation, generally associate with more favorable prognosis, and serve as a predictive biomarker of response to luspatercept. However, not all <italic>...

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Literature Corpus work: bafe0dd8-5d87-5ad3-804d-882d6c14a1d8
DOI: 10.21203/rs.3.rs-2802265/v1

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