Article

Ligand-Independent Activation of Hedgehog Signaling in Diffuse Large B-Cell Lymphoma: Role of PTCH1 Promoter Hypermethylation

2026-05-26

Abstract excerpt

<title>Abstract</title> <p> Background Hedgehog (HH) signaling is aberrantly activated in diffuse large B-cell lymphoma (DLBCL) and contributes to tumor proliferation and drug resistance. However, ligand-independent activation mechanisms, including gene mutations and epigenetic modifications, remain poorly defined. Methods We performed targeted sequencing of 475 lymphoma-related genes in 106 DLBCL patients and...

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Literature Corpus work: 476f71bb-5ff9-5d75-8167-1b70cf55525f
DOI: 10.21203/rs.3.rs-9662268/v1

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