Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metastatic basal cell carcinoma with amplification of PD-L1: exceptional response to anti-PD1 therapy

19 Oct 2016

Abstract excerpt

Abstract Metastatic basal cell carcinomas are rare malignancies harbouring Hedgehog pathway alterations targetable by SMO antagonists (vismodegib/sonidegib). We describe, for the first time, the molecular genetics and response of a patient with Hedgehog inhibitor-resistant metastatic basal cell carcinoma who achieved rapid tumour regression (ongoing near complete remission at 4 months) with nivolumab (anti-PD1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hedgehog Signaling Pathway Studies
Share to Nonmelanoma Skin Cancer Studies
Share to Tumors and Oncological Cases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27942391
DOI: 10.1038/npjgenmed.2016.37

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metastatic basal cell carcinoma with amplification of PD-L1: exceptional response to anti-PD1 therapyPMID 27942391Read ↗

Genomic landscape of advanced basal cell carcinoma: Implications for precision treatment with targeted and immune therapiesSemantic proximity Read ↗

Acquisition of drug resistance in basal cell nevus syndrome tumors through basal to squamous cell carcinoma transitionSemantic proximity Read ↗

Profile of basal cell carcinoma mutations and copy number alterations - focus on gene-associated noncoding variantsSemantic proximity Read ↗

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma.Semantic proximity Read ↗

Genomic Stability in Syndromic Basal Cell Carcinoma.Semantic proximity Read ↗

Resistance to SMO Inhibitors in Advanced Basal Cell Carcinoma: A Case Highlighting the Role of Molecular Tumor Profiling.Semantic proximity Read ↗

Molecular profiling of basal cell carcinomas in young patients.Semantic proximity Read ↗

The molecular genetics underlying basal cell carcinoma pathogenesis and links to targeted therapeutics.Semantic proximity Read ↗

Investigation of Genetic Mutations in High-risk and Low-risk Basal Cell Carcinoma in a Non-Caucasian Population by Whole Exome Sequencing.Semantic proximity Read ↗

Basal cell carcinosarcoma with PTCH1 mutations in both epithelial and sarcomatoid primary tumor components and in the sarcomatoid metastasis.Semantic proximity Read ↗

Molecular Mechanisms and Targeted Therapies of Advanced Basal Cell CarcinomaSemantic proximity Read ↗

The transcriptional landscape analysis of basal cell carcinomas reveals novel signalling pathways and actionable targetsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.