Article

A mesoporous oxygen-vacancy-rich ZnO nanoplatform as a catalytic therapeutic hub for osteoarthritis therapy by TRIM15-targeted stem cell rejuvenation

2026-08-11

Abstract excerpt

<title>Abstract</title> <p> Osteoarthritis (OA) lacks disease-modifying treatments, partly because aging creates an oxidative-senescent joint niche that accelerates cartilage degeneration and weakens endogenous MSC-mediated repair. We found that aged OA cartilage harboured TRIM15-high MSC-like cells, whereas aged joint-derived MSCs exhibited zinc depletion, defective mitophagy and impaired chondrogenesis. To add...

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Literature Corpus work: 474e5908-3d41-56cf-a7c8-6de6a1b594e9
DOI: 10.21203/rs.3.rs-10146539/v1

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