Article

TP53 Inhibited AR Signaling Promote Enzalutamide Resistance in LNCaP cell

2021-08-13

Abstract excerpt

<h4>Background: </h4> To perform gene screening and search key knockout gene associated with enzalutamide resistance in LNCaP cells. <h4>Methods: </h4>: Genome-scale CRISPR-Cas9 transfection were done to screen genes associated with enzalutamide resistance in LNCaP cells. Bioinformatic analysis of TP53 and AR expression correlated with prostate adenocarcinoma by using TCGA database. Knockout interfering RNA (shRNA...

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Literature Corpus work: 471f7d12-542c-5355-be2a-0242d398419c
DOI: 10.21203/rs.3.rs-723293/v1

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