Article
Sex-specific and genotype-specific differences in vocalization development in FMR1 knockout mice.
Neuroreport - 14 Dec 2016
Reynolds Conner D, Nolan Suzanne O, Jefferson Taylor, Lugo Joaquin N
Abstract excerpt
Fragile X syndrome is a neurodevelopmental disorder caused by a trinucleotide (CGG) hyperexpansion in the FMR1 gene, functionally silencing transcription of the fragile X mental retardation protein (FMRP). This disorder is characterized by impaired cognition, communication, and social behavior. The aim of this study was to investigate the development of ultrasonic vocalization (USV) behavior in a Fmr1-deficient...
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