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A role for BCL2L13 and autophagy in germline purifying selection of mtDNA

2022-09-02

Abstract excerpt

Mammalian mitochondrial DNA (mtDNA) is inherited uniparentally through the female germline without undergoing recombination. This poses a major problem as deleterious mtDNA mutations must be eliminated to avoid a mutational meltdown over generations. At least two mechanisms that can decrease the mutation load during maternal transmission are operational: a stochastic bottleneck for mtDNA transmission from mother t...

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Identifiers and source

Literature Corpus work
46cb58e8-cda7-5fec-9b0c-bab42045235e
DOI
10.1101/2022.09.02.506367
Open publication

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A role for BCL2L13 and autophagy in germline purifying selection of mtDNADOI 10.1101/2022.09.02.506367
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