Article

A Chemically Stable Retinoic Acid Mimic Drives Regeneration and Behavioral Recovery after Spinal Cord Injury

2025-11-07

Abstract excerpt

Injury to the adult central nervous system triggers minimal axonal regeneration, partly due to the limited activation of intrinsic growth programs. Retinoic acid (RA) signaling has been shown to promote modest regenerative responses, but its clinical utility is restricted by poor biochemical stability and short-lived receptor engagement. Here, we report a small molecule based synthetic RA mimic, DM04, that recapit...

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Literature Corpus work: 46aee49e-2337-574d-8cdf-7eb1e88a1551
DOI: 10.1101/2025.11.05.686894

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