Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Palladin isoforms 3 and 4 regulate cancer-associated fibroblast pro-tumor functions in pancreatic ductal adenocarcinoma

15 Feb 2021

Abstract excerpt

Pancreatic Ductal Adenocarcinoma (PDAC) has a five-year survival under 10%. Treatment is compromised due to a fibrotic-like stromal remodeling process, known as desmoplasia, which limits therapeutic perfusion, supports tumor progression, and establishes an immunosuppressive microenvironment. These processes are driven by cancer-associated fibroblasts (CAFs), functionally activated through transforming growth...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer, Hypoxia, and Metabolism
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33589694
DOI: 10.1038/s41598-021-82937-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Palladin isoforms 3 and 4 regulate cancer-associated fibroblast pro-tumor functions in pancreatic ductal adenocarcinomaPMID 33589694Read ↗

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancerSemantic proximity Read ↗

Fibroblast Heterogeneity in the Pancreatic Tumor MicroenvironmentSemantic proximity Read ↗

The Cellular Origins of Cancer-Associated Fibroblasts and Their Opposing Contributions to Pancreatic Cancer GrowthSemantic proximity Read ↗

Three Distinct Stroma Types in Human Pancreatic Cancer Identified by Image Analysis of Fibroblast Subpopulations and CollagenSemantic proximity Read ↗

Pancreatic Fibroblast Heterogeneity: From Development to CancerSemantic proximity Read ↗

Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumorsSemantic proximity Read ↗

Inter‐ and intra‐tumoural heterogeneity in cancer‐associated fibroblasts of human pancreatic ductal adenocarcinomaSemantic proximity Read ↗

BNIP3 + cancer-associated fibroblasts and their associated genes are accelerators of pancreatic cancerSemantic proximity Read ↗

The role of microRNAs in the modulation of cancer-associated fibroblasts activity during pancreatic cancer pathogenesisSemantic proximity Read ↗

Transcriptome Landscape of Cancer‐Associated Fibroblasts in Human PDACSemantic proximity Read ↗

ARP2 /3 complex affects myofibroblast differentiation and migration in pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Cancer Associated Fibroblast (CAF) Regulation of PDAC Parenchymal (CPC) and CSC Phenotypes Is Modulated by ECM CompositionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.