Article

Molecular basis for the increased membrane fusion activity of the Ebola virus glycoprotein A82V variant from the 2013-2016 epidemic: insights from simulations and experiments

2024-10-31

Abstract excerpt

<h4>ABSTRACT</h4> During the 2013-2016 Ebola virus epidemic in Western Africa, an A82V mutation emerged in the envelope glycoprotein (GP) that persisted in most circulating isolates. Previous studies demonstrated that A82V increased GP-mediated membrane fusion and altered its dependence on host factors. The mechanistic basis for these observations, in particular the impact of A82V on the conformational changes in...

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Literature Corpus work: c79fb636-44a3-5f98-a78d-a82f938ae1b4
DOI: 10.1101/2024.10.28.620686

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