Article

Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress

2023-01-22

Abstract excerpt

Activated Notch signaling is highly prevalent in T-cell acute lymphoblastic leukemia (T-ALL) but pan-Notch inhibitors were toxic in clinical trials. To find alternative ways to target Notch signals, we investigated Cell division cycle 73 (Cdc73), which is a Notch cofactor and component of transcriptional machinery, a potential target in T-ALL. While we confirmed previous work that CDC73 interacts with NOTCH1, we a...

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Literature Corpus work: 46843e6c-6a55-5daa-9e83-6901e4d3b887
DOI: 10.1101/2023.01.22.525059

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