Article

Discovering functionally important sites in proteins

2022-07-15

Abstract excerpt

Proteins play important roles in biology, biotechnology and pharmacology, and missense variants are a common cause of disease. Discovering functionally important sites in proteins is a central but difficult problem because of the lack of large, systematic data sets. Sequence conservation can highlight residues that are functionally important but is often convoluted with a signal for preserving structural stability...

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Literature Corpus work: 464e6a1c-e1be-561a-9e42-a0c34c1c8f2c
DOI: 10.1101/2022.07.14.500015

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