Article

Decreased endothelial cell retinoic acid signaling accelerates progression of single ventricle pulmonary arteriovenous malformations

2025-12-11

Abstract excerpt

<h4>Background</h4> Pulmonary arteriovenous malformations (PAVMs) are vascular complications that universally develop in patients with single ventricle congenital heart disease after Glenn surgery. However, the pathophysiological mechanisms underlying single ventricle PAVMs are poorly understood. To comprehensively evaluate molecular changes post-Glenn, we performed single-cell RNA sequencing (scRNAseq) on rat lu...

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Literature Corpus work: 4641af5e-ba28-57be-b07b-1340fea48e3a
DOI: 10.64898/2025.12.08.693095

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