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Article

Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration.

EBioMedicine - 1 Feb 2020

Wert Katherine J, Velez Gabriel, Kanchustambham Vijaya L, Shankar Vishnu, Evans Lucy P, Sengillo Jesse D, Zare Richard N, Bassuk Alexander G, Tsang Stephen H, Mahajan Vinit B

Abstract excerpt

BACKGROUND: Neurodegenerative diseases are incurable disorders caused by progressive neuronal cell death. Retinitis pigmentosa (RP) is a blinding neurodegenerative disease that results in photoreceptor death and progresses to the loss of the entire retinal network. We previously found that proteomic analysis of the adjacent vitreous served as way to indirectly biopsy the retina and identify changes in the retinal...

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Topics

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Share to Chromatography, Liquid
Share to Cyclic Nucleotide Phosphodiesterases, Type 6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dietary Supplements

Share to Liquid Biopsy

Share to Oxidative Phosphorylation

Share to Photoreceptor Cells, Vertebrate

Share to Retinal Degeneration

Share to Tandem Mass Spectrometry

Source

Open in PubMed Open full text

Identifiers

PMID: 32028070
DOI: 10.1016/j.ebiom.2020.102636
PMCID: PMC7005447

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