Establishing guidelines to harmonize tumor mutational burden (TMB): in silico assessment of variation in TMB quantification across diagnostic platforms: phase I of the Friends of Cancer Research TMB Harmonization Project.

doi:10.1136/jitc-2019-000147

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Article

Establishing guidelines to harmonize tumor mutational burden (TMB): in silico assessment of variation in TMB quantification across diagnostic platforms: phase I of the Friends of Cancer Research TMB Harmonization Project.

Journal for immunotherapy of cancer - 1 Mar 2020

Merino Diana M, McShane Lisa M, Fabrizio David, Funari Vincent, Chen Shu-Jen, White James R, Wenz Paul, Baden Jonathan, Barrett J Carl, Chaudhary Ruchi, Chen Li, Chen Wangjuh Sting, Cheng Jen-Hao, Cyanam Dinesh, Dickey Jennifer S, Gupta Vikas, Hellmann Matthew, Helman Elena, Li Yali, Maas Joerg, Papin Arnaud, Patidar Rajesh, Quinn Katie J, Rizvi Naiyer, Tae Hongseok, Ward Christine, Xie Mingchao, Zehir Ahmet, Zhao Chen, Dietel Manfred, Stenzinger Albrecht, Stewart Mark, Allen Jeff

Abstract excerpt

BACKGROUND: Tumor mutational burden (TMB), defined as the number of somatic mutations per megabase of interrogated genomic sequence, demonstrates predictive biomarker potential for the identification of patients with cancer most likely to respond to immune checkpoint inhibitors. TMB is optimally calculated by whole exome sequencing (WES), but next-generation sequencing targeted panels provide TMB estimates in a...

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Identifiers

PMID: 32217756
DOI: 10.1136/jitc-2019-000147
PMCID: PMC7174078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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