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Article

Deciphering the toxicity of polyhexamethylene guanidine phosphate in lung carcinogenesis: Mutational profiles and molecular mechanisms.

Chemosphere - 1 Nov 2024

Lee Hong, Jeong Sang Hoon, Baek Yong-Wook, Lee Hyejin, Sa Jason K, Lee Ji Yoon, Lee Yu-Seon, Nam Yoon Jeong, Kim Jaeyoung, Kim Jonghoon, Choi Jin Young, Park Su A, Kim Je Hyeong, Park Yoon Hee, Lim Jungyun, Kim Young-Hee, Park Eun-Kee, Kim Cherry, Lee Ju-Han

Abstract excerpt

Polyhexamethylene guanidine (PHMG) is widely utilized in personal hygiene products due to its bactericidal, non-volatile, and hydrophilic properties. However, the long-term toxic effects and underlying mechanisms associated with respiratory exposure to the commonly used form, PHMG phosphate (PHMG-p), are still insufficiently understood. This study aims to elucidate the types of pulmonary lesions and the incidence...

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PMID: 39577803
DOI: 10.1016/j.chemosphere.2024.143785

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