Article

Machine Learning Analysis of Cilia-Driven Particle Transport Distinguishes Primary Ciliary Dyskinesia Cilia from Normal Cilia

2025-11-04

Abstract excerpt

<h4>Rational</h4> Primary ciliary dyskinesia (PCD) is a genetic condition that results in dysmotile cilia and abnormal mucociliary clearance. Despite advances in understanding the pathogenesis of PCD, diagnosis continues to be challenging. Here we used feature-based machine learning and image-based deep learning to objectively quantify the directed particle transport of motile cilia and detect PCD-related cilia d...

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Literature Corpus work: 4f56dc89-c7eb-5e80-85a1-e8b2990f0c43
DOI: 10.1101/2025.11.02.686130

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