Article

A TROP2/Claudin Program Mediates Immune Exclusion to Impede Checkpoint Blockade in Breast Cancer

2024-12-05

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Immune exclusion inhibits anti-tumor immunity and response to immunotherapy, but its mechanisms remain poorly defined. In triple-negative breast cancer (TNBC), an aggressive and generally immune-rich subtype, an immune-cold microenvironment predicts poor prognosis due to a limited response to chemotherapy and immune checkpoint inhibitors. This study aimed to identify mechani...

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Literature Corpus work: 453a8fc4-2203-511a-a1b6-9d3581c11437
DOI: 10.1101/2024.12.02.626446

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