Article

Increased Prolylcarboxypeptidase Expression Can Serve as Biomarker of Senescence in Culture

2024-03-28

Abstract excerpt

Prolylcarboxypeptidase (PRCP, PCP, Lysosomal Pro-X-carboxypeptidase, Angiotensinase C) controls angiotensin - and kinin- induced cell signaling. Elevation of PRCP appear to be activated in chronic inflammatory diseases (cardiovascular disease (CVD), diabetes) in proportion to severity. Vascular endothelial cell senescence and mitochondrial dysfunction have consistently been shown in models of CVD in aging. The cel...

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Literature Corpus work: 44fb8045-f201-53f7-b5c5-8697728808f7
DOI: 10.20944/preprints202403.1780.v1

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