Article

kTWAS: Integrating kernel-machine with transcriptome-wide association studies improves statistical power and reveals novel genes

2020-06-29

Abstract excerpt

The power of genotype-phenotype association mapping studies increases greatly when contributions from multiple variants in a focal region are meaningfully aggregated. Currently, there are two popular categories of variant aggregation methods. Transcriptome-wide association studies (TWAS) represent a category of emerging methods that select variants based on their effect on gene expressions, providing pretrained li...

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Literature Corpus work: 44f68cc7-e294-5414-a6fb-3729837145e2
DOI: 10.1101/2020.06.29.177121

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