Article

Genome Wide Association Analysis of Two Pore Domain Potassium Channel Gene Regions Reveals Multiple Pain-Associated Signals

2026-01-01

Abstract excerpt

Two-pore domain potassium (K2P) channels are novel analgesic drug targets with existing in vitro and in vivo validation, however genetic associations in large scale populations have not been widely reported. By examining two comprehensive genetic databases (UK Biobank & FinnGen) and 136 pain-related traits, we highlight that multiple pain-associated signals are present within 500 kb of K2P gene transcripts, with...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 44e17a7a-7585-51ce-bdb0-ba3519ca6251
DOI: 10.64898/2025.12.24.25342351

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome Wide Association Analysis of Two Pore Domain Potassium Channel Gene Regions Reveals Multiple Pain-Associated SignalsDOI 10.64898/2025.12.24.25342351Read

Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits.Semantic proximity Read

Rare variant associations of chronic pain conditions in the UK Biobank Whole Exome SequencingSemantic proximity Read

A systematic review of genome-wide association studies for pain, nociception, neuropathy, and pain treatment responses.Semantic proximity Read

Human pain genetics database: a resource dedicated to human pain genetics research.Semantic proximity Read

Unlocking Pain Therapeutics: How to Find the Right Target and Treatment ApproachSemantic proximity Read

Genome-wide association study of nociceptive musculoskeletal pain treatment response in UK BiobankSemantic proximity Read

Biological pathways and genetic variables involved in pain.Semantic proximity Read

Genome-Wide Association Study Identifies Novel Genetic Variants Associated with Widespread Pain in the UK Biobank (N=172,230)Semantic proximity Read

Rare variant association studies: Significance, methods, and applications in chronic pain studies.Semantic proximity Read

Genome-wide association study identifies novel genetic variants associated with widespread pain in the UK Biobank (N = 172,230).Semantic proximity Read

GWAS of extended prescription analgesic use identifies genetic loci in chronic pain.Semantic proximity Read

Genetic predictors of human chronic pain conditions.Semantic proximity Read