Article

Loss of Adaptive DNA Breaks in Alzheimer’s Disease Brains

2023-12-12

Abstract excerpt

<h4>Background</h4> DNA breaks accumulate in Alzheimer’s disease (AD) brains. While their role as true genomic lesions is recognized, DNA breaks also support cognitive function by facilitating the expression of activity-dependent immediate early genes (IEGs). This process involves TOP2B, a DNA topoisomerase that catalyzes the formation of DNA double-strand breaks (DSBs). <h4>Objective</h4> To characterize how AD...

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Literature Corpus work: 44ce932d-8988-50c2-8027-328320f8bcc4
DOI: 10.1101/2023.12.11.566423

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