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Article

MiR-145 alleviates Hcy-induced VSMC proliferation, migration, and phenotypic switch through repression of the PI3K/Akt/mTOR pathway.

Histochemistry and cell biology - 1 May 2020

Zhang Minghao, Li Fan, Wang Xiuyu, Gong Jian, Xian Yushan, Wang Guan, Zheng Zihan, Shang Chenxu, Wang Bo, He Yanhao, Wang Weirong, Lin Rong

Abstract excerpt

The proliferation, migration, and cellular morphology of vascular smooth muscle cells (VSMCs) play important roles in the pathogenesis of atherosclerosis (AS). Homocysteine (Hcy) is a sulfur-containing amino acid, which is an intermediate product of methionine metabolism. Hcy can induce proliferation, migration, and phenotypic switch of VSMCs, but details of these mechanisms are still unclear. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32124010
DOI: 10.1007/s00418-020-01847-z

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