Development of rapid and simple Xeno Nucleic Acid (XNA) sensor-based microRNA detection method for Parkinson’s disease diagnostics

Abstract excerpt

<title>Abstract</title> <p>Reliable quantification of circulating microRNAs (miRNAs) has been limited by amplification bias, nonlinear signal distortion, and poor cross-platform reproducibility in qRT-PCR, sequencing, and hybridization-based assays. This persistent analytical barrier represents a major unmet demand in miRNA diagnostics, preventing biologically validated miRNA biomarkers from achieving clinical tr...

Topics

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• Carcinoma, Non-Small-Cell Lung
• CRISPR-Cas Systems
• DNA
• Lung Neoplasms
• MicroRNAs
• Nucleic Acid Amplification Techniques
• Peptide Nucleic Acids
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

44c1946f-2c81-54eb-b89e-a33f75acee60

DOI

10.21203/rs.3.rs-9434513/v1