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Article

Duration-dependent alterations of lipid profiles and microvascular complications in GCK-MODY.

Biochimica et biophysica acta. Molecular basis of disease - 1 Mar 2026

Huang Yadi, Fan Yuxin, Liu Yang, Liu Xuan, Li Wei, Yang Ying, Zhang Ziyue, Ma Shifeng, Ji Shuhui, Chen Shanshan, Shu Hua, Feng Wenli, Wang Kunling, He Qing, Qi Wenjun, Liu Ming, Li Xin, Fan Yu

Abstract excerpt

Heterozygous inactivating mutations in the glucokinase (GCK) gene cause maturity-onset diabetes of the young type 2 (GCK-MODY), a monogenic diabetes subtype characterized by stable hyperglycemia and low complication risk. However, the long-term effects of distinct dietary patterns on lipid metabolism and chronic complications in GCK-MODY remain poorly understood. In this study, we employed a knock-in mouse model...

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Share to Diabetes Mellitus, Type 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41386400
DOI: 10.1016/j.bbadis.2025.168137

Genes

GCK

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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