Article

High-Density Wild-Type IL-2 Nanoparticles Preferentially Enhance CD8⁺ T-Cell Expansion and Reprogram the Tumor Microenvironment

2026-07-15

Abstract excerpt

Low response rates to immune checkpoint inhibitors (ICIs) in solid tumors are often driven by insufficient tumor-infiltrating CD8⁺ T cells and immunosuppressive tumor microenvironment (TME). Although interleukin-2 (IL-2) potently expands and activates CD8⁺ T cells, its clinical use is limited by rapid clearance, dose-limiting toxicity, and regulatory T cell (T reg ) stimulation. Engineered IL-2 variants have not...

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Literature Corpus work: 44b02f72-7019-5458-aad3-8175b36dd4d6
DOI: 10.64898/2026.07.14.738558

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