Article
Spectraplakins promote microtubule-mediated axonal growth by functioning as structural microtubule-associated proteins and EB1-dependent +TIPs (tip interacting proteins).
The Journal of neuroscience : the official journal of the Society for Neuroscience - 4 Jul 2012
Alves-Silva Juliana, Sánchez-Soriano Natalia, Beaven Robin, Klein Melanie, Parkin Jill, Millard Thomas H, Bellen Hugo J, Venken Koen J T, Ballestrem Christoph, Kammerer Richard A, Prokop Andreas
Abstract excerpt
The correct outgrowth of axons is essential for the development and regeneration of nervous systems. Axon growth is primarily driven by microtubules. Key regulators of microtubules in this context are the spectraplakins, a family of evolutionarily conserved actin-microtubule linkers. Loss of function of the mouse spectraplakin ACF7 or of its close Drosophila homolog Short stop/Shot similarly cause severe axon...
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