Article

Polymorphism of alcohol and aldehyde dehydrogenase genes and alcoholic cirrhosis in chinese patients

1994-02-01

Abstract excerpt

Liver alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), the principal enzymes responsible for the oxidation of ethanol, are polymorphic at the ADH 2, ADH3 and ALDH 2 loci in human beings. Our previous studies have shown that, compared with nonalcoholic individuals, Chinese alcoholic patients without liver disease had significantly lower frequencies of the ADH 2*2 and ADH 3*1 alleles, which encode high...

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Literature Corpus work: 447cca7c-84fa-5842-a287-8473cc59aa4f
DOI: 10.1002/hep.1840190214

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