Article
Polymorphism of alcohol and aldehyde dehydrogenase genes and alcoholic cirrhosis in Chinese patients.
Hepatology (Baltimore, Md.) - 1 Feb 1994
Chao Y C, Liou S R, Chung Y Y, Tang H S, Hsu C T, Li T K, Yin S J
Abstract excerpt
Liver alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), the principal enzymes responsible for the oxidation of ethanol, are polymorphic at the ADH2, ADH3 and ALDH2 loci in human beings. Our previous studies have shown that, compared with nonalcoholic individuals, Chinese alcoholic patients without liver disease had significantly lower frequencies of the ADH2*2 and ADH3*1 alleles, which encode high...
Topics
- Alcohol Dehydrogenase
- Alcoholism
- Aldehyde Dehydrogenase
- Alleles
- Base Sequence
- DNA Primers
- Duodenal Ulcer
- Gene Frequency
- Genotype
- Hepatitis, Viral, Human
- Humans