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Integration of Human Protein Sequence and Protein-Protein Interaction Data by Graph Autoencoder to Identify Novel Protein-Abnormal Phenotype Associations.

Cells - 10 Aug 2022

Liu Yuan, He Ruirui, Qu Yingjie, Zhu Yuan, Li Dianke, Ling Xinping, Xia Simin, Li Zhenqiu, Li Dong

Abstract excerpt

Understanding gene functions and their associated abnormal phenotypes is crucial in the prevention, diagnosis and treatment against diseases. The Human Phenotype Ontology (HPO) is a standardized vocabulary for describing the phenotype abnormalities associated with human diseases. However, the current HPO annotations are far from completion, and only a small fraction of human protein-coding genes has HPO...

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PMID: 36010562
DOI: 10.3390/cells11162485
PMCID: PMC9406402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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