Article

A clustered regularly interspaced short palindromic repeats knockout method to reveal methyl-CpG binding domain 4 function

2022-11-12

Abstract excerpt

DNA methylation is an epigenetic mechanism tailored for DNA repression, engineered for regulating genetic expression without direct manipulation of the nucleotide sequence. One component of this process includes methyl-binding proteins (MBD), which have an affinity for methyl groups, and they competitively inhibit transcription factors from binding with genetic promoters. Interestingly, MBD4 is unique because, as...

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Literature Corpus work: 44479929-8481-5629-b764-ff38e0e2bbfb
DOI: 10.14293/s2199-1006.1.sor-.pprduyu.v1

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