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Article

3D Chromatin Organization Involving MEIS1 Factor in the cis-Regulatory Landscape of GJB2.

International journal of molecular sciences - 23 Jun 2022

Le Nabec Anaïs, Blotas Clara, Briset Alinéor, Collobert Mégane, Férec Claude, Moisan Stéphanie

Abstract excerpt

The human genome is covered by 8% of candidate cis-regulatory elements. The identification of distal acting regulatory elements and an understanding of their action are crucial to determining their key role in gene expression. Disruptions of such regulatory elements and/or chromatin conformation are likely to play a critical role in human genetic diseases. Non-syndromic hearing loss (i.e., DFNB1) is mostly due to...

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Identifiers

PMID: 35805969
DOI: 10.3390/ijms23136964
PMCID: PMC9266880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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