Article

GEMC1 and CCNO are required for efferent duct development and male fertility

2018-02-01

Abstract excerpt

GEMC1 is a Geminin family protein that triggers the E2F4/5-mediated transcriptional activation of target genes, including many required for multiciliogenesis, such as Mcidas, FoxJ1 and Ccno . Male mice lacking either Gemc1 or Ccno were found to be infertile, but the origin of this defect has remained unclear. Here we show that mice lacking either Gemc1 or Ccno showed a nearly empty seminiferous tubule phenot...

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Literature Corpus work: 4442be0b-b9c9-5012-a4ca-02a8a4efa5fb
DOI: 10.1101/258418

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