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Article

Defects in efferent duct multiciliogenesis underlie male infertility in GEMC1, MCIDAS or CCNO deficient mice

1 Jan 2019

Abstract excerpt

GEMC1 and MCIDAS are Geminin family proteins that transcriptionally activate E2F4/5-target genes during multiciliogenesis, including FoxJ1 and Ccno. Male mice lacking Gemc1, Mcidas or Ccno were found to be infertile, but the origin of this defect has remained unclear. Here we show that all three genes are necessary for the generation of functional multiciliated cells in the efferent ducts that are required for...

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PMID: 30936178
DOI: 10.1242/dev.162628

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