Article

A Novel lncRNA-Mediated Signaling Axis Governs Cancer Stemness and Splicing Reprogramming in Hepatocellular Carcinoma with Therapeutic Potential

2025-09-23

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> Aberrant alternative splicing (AS) contributes to cancer stemness and progression in hepatocellular carcinoma (HCC). However, the regulatory roles of long noncoding RNAs (lncRNAs) in linking AS dysregulation to tumor stemness remain elusive. <bold>Methods</bold> We performed integrated bulk and single-cell RNA-Seq analyses combined with functional assays to ident...

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Literature Corpus work: 443449f4-6900-5c36-aced-6751c2849e87
DOI: 10.21203/rs.3.rs-6969931/v1

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