Article

Discovery of circulating cell-free DNA 5hmC biomarkers for peritoneal metastasis in colorectal and appendiceal cancer

2025-09-21

Abstract excerpt

<h4>Introduction</h4> Peritoneal metastases (PM) are associated with poor prognosis in patients with colorectal cancer (CRC) or appendiceal adenocarcinoma (AA), yet detection of PM is unreliable using current circulating DNA technology. Leveraging novel 5hmC-seal technology to detect ultra-low amounts of DNA in plasma, we demonstrate the feasibility of 5-hydroxymethylcytosine (5hmC) signatures derived from circul...

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Literature Corpus work: 289a9123-cd6f-53fe-9ee5-8970a5aa4f75
DOI: 10.1101/2025.09.18.676945

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