Article

A Polygenic Quincunx

2023-07-19

Abstract excerpt

Sequential addition of SNPs (single nucleotide polymorphism) to a risk model repeatedly splits risk groups in two, generating a branching tree. As SNPs are independent, the path of an individual through the tree is a form of random walk. This resembles the path of a ball through a Galton quincunx, but the rules for a polygenic quincunx are more complex. The result is that individuals zigzag to higher and lower ris...

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Literature Corpus work: 442c3527-0f7f-536e-bc2a-bff0f706468d
DOI: 10.1101/2023.07.18.549486

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