Article

HERMES: Holographic Equivariant neuRal network model for Mutational Effect and Stability prediction

2024-07-13

Abstract excerpt

Accurately predicting how amino acid substitutions alter protein function is a central challenge in biology, with applications from interpreting disease variants to designing vaccines and therapeutics. We introduce HERMES, a family of fast, structure-based models that predict mutational effects from the local atomic environment around each residue. Pre-trained on masked amino acid prediction, HERMES shows strong z...

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Literature Corpus work: 43cc29ec-63fb-5e3f-afc0-55e55b3ae974
DOI: 10.1101/2024.07.09.602403

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