Article
LICHEN: Light-chain Immunoglobulin sequence generation Conditioned on the Heavy chain and Experimental Needs
2025-08-07
Abstract excerpt
In developing therapeutic antibodies, the heavy chain is often prioritised due to its higher variability and its central role in antigen binding. An appropriate pairing of the light sequence is however important for antibody function. Here we present LICHEN, a heavy chain conditioned light sequence generation tool that enables collaborative light sequence design by leveraging computational capabilities alongside e...
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Identifiers and source
- Literature Corpus work
- 437b7246-2e56-5605-94b3-f87ecd727b0d
- DOI
- 10.1101/2025.08.06.668938