Article

DNA break clustering inside repair domains predicts cell death and mutation frequency in human fibroblasts and in Chinese hamster cells for a 10 <sup>3</sup> x range of linear energy transfers

2020-11-30

Abstract excerpt

<h4>ABSTRACT</h4> Cosmic radiation, composed of high charged and energy (HZE) particles, causes cell death and mutations that can subsequently lead to cancers. Radiation-mediated mutations are induced by inter- and intra-chromosomal rearrangements (translocations, deletions, inversions) that are triggered by misrepaired DNA breaks, especially double-strand breaks (DSBs). In this work, we introduce a new model to...

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Literature Corpus work: 435cf388-544d-59a6-9b2c-295e33c6d999
DOI: 10.1101/2020.11.30.403717

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DNA break clustering inside repair domains predicts cell death and mutation frequency in human fibroblasts and in Chinese hamster cells for a 10 <sup>3</sup> x range of linear energy transfersDOI 10.1101/2020.11.30.403717Read

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