Article

DNA double-strand breaks in and beyond heavy-ion tracks: the role of Base Excision Repair and DNA-damage complexity

2025-07-22

Abstract excerpt

<title>Abstract</title> <p>Space radiation poses a threat to human health during space missions. Its biological effect largely depends on heavy ions. These induce highly clustered DNA damage along their tracks, thus impacting genomic integrity and cancer risk. δ-electrons induced by fast heavy ions lead to further DNA damage outside ion tracks, which resembles that of sparsely-ionizing radiation.Here we show that...

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Literature Corpus work: 9f969006-5c4f-5de5-9c5f-3a613aebef57
DOI: 10.21203/rs.3.rs-6975573/v1

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