Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacological Polarization of Tumor-Associated Macrophages Toward a CXCL9 Antitumor Phenotype.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Apr 2024

Enbergs Noah, Halabi Elias A, Goubet Anne-Gaëlle, Schleyer Kelton, Fredrich Ina R, Kohler Rainer H, Garris Christopher S, Pittet Mikaël J, Weissleder Ralph

Abstract excerpt

Tumor-associated macrophages (TAM) are a diverse population of myeloid cells that are often abundant and immunosuppressive in human cancers. CXCL9Hi TAM has recently been described to have an antitumor phenotype and is linked to immune checkpoint response. Despite the emerging understanding of the unique antitumor TAM phenotype, there is a lack of TAM-specific therapeutics to exploit this new biological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CXCL9 gene
Share to Macrophages

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms

Share to Phenotype

Share to Tumor-Associated Macrophages

Source

Open in PubMed Open full text

Identifiers

PMID: 38342608
DOI: 10.1002/advs.202309026
PMCID: PMC11022742

Genes

CXCL9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacological Polarization of Tumor-Associated Macrophages Toward a CXCL9 Antitumor Phenotype.PMID 38342608Read ↗

A Bacterial and Ganglioside-based Nanoparticle Initiates Reprogramming of Macrophages and Promotes Antitumor Phenotypes.Semantic proximity Read ↗

Targeting tumor associated macrophages (TAMs) via nanocarriers.Semantic proximity Read ↗

Deciphering tumor microenvironment: CXCL9 and SPP1 as crucial determinants of tumor-associated macrophage polarity and prognostic indicatorsSemantic proximity Read ↗

Microparticle-Delivered Cxcl9 Prolongs Braf Inhibitor Efficacy in Melanoma.Semantic proximity Read ↗

Host-functionalization of macrin nanoparticles to enable drug loading and control tumor-associated macrophage phenotype.Semantic proximity Read ↗

Microparticle-delivered Cxcl9 prolongs Braf inhibitor efficacy in melanomaSemantic proximity Read ↗

Genetically engineered macrophages persist in solid tumors and locally deliver therapeutic proteins to activate immune responsesSemantic proximity Read ↗

Engineered GM-CSF polarizes protumorigenic tumor-associated macrophages to an antitumorigenic phenotype and potently synergizes with IL-12 immunotherapy.Semantic proximity Read ↗

Cancer-induced systemic myeloid dysfunction: Implications for treatment and a novel nanoparticle approach for its correctionSemantic proximity Read ↗

Systemic delivery of a CXCR4-CXCL12 signaling inhibitor encapsulated in synthetic protein nanoparticles for glioma immunotherapySemantic proximity Read ↗

The benefits of combining an immunomodulator with a chemotherapy agent in chondrosarcoma : a proof of concept with mifamurtideSemantic proximity Read ↗

Intratumoral IL12 mRNA administration activates innate and adaptive pathways in checkpoint inhibitor resistant tumors resulting in complete responsesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.