Article

Na <sup>+</sup> /H <sup>+</sup> antiporter activity by respiratory complex I controls mitochondrial Δψ and is impaired in LHON disease

2023-05-30

Abstract excerpt

The mitochondrial electron transport chain (mETC) converts the energy of substrate oxidation into a H + electrochemical gradient (Δp), which is composed by an inner mitochondrial membrane (IMM) potential (ΔΨmt) and a pH gradient (ΔpH). So far, ΔΨmt has been assumed to be composed exclusively by H + . Mitochondrial Ca 2+ and Na + homeostasis, which are essential for cellular function, are controlled by exchange...

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Literature Corpus work: 432b7505-78e7-5c4d-9c59-23131854cbc5
DOI: 10.1101/2023.05.30.542932

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