Article
The voltage-gated K+ channel subunit Kv1.1 links kidney and brain.
The Journal of clinical investigation - 1 Apr 2009
Ellison David H
Abstract excerpt
Analysis of Mendelian Mg2+ wasting disorders helps us to unravel the mechanisms of Mg2+ homeostasis. In this issue of the JCI, Glaudemans andcolleagues show that mutations in voltage-gated K+ channel subtype 1.1(Kv1.1) cause autosomal dominant hypomagnesemia in humans (see the related article beginning on page 936). Interestingly, other mutations in the same protein cause the neurological disease episodic ataxia...
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