Article

Evolution of the SARS-CoV-2 main protease under fitness constraints imposed by folding stability and activity

2026-07-22

Abstract excerpt

<title>Abstract</title> <p>The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) continues to evolve and diversify, leading to the emergence of immune-evasive variants and underscoring the need for complementary antiviral strategies targeting conserved viral machinery. In this context, the main protease (Mpro) represents a potential therapeutic target because of its central role in viral replication an...

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Literature Corpus work: 431faaf9-7de5-513d-99bd-fad3e9b7256a
DOI: 10.21203/rs.3.rs-10432418/v1

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